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His closest rival is Leni Robredo who beat Mr Marcos in the 2016 vice-presidential elections.
But polls this campaign have consistently shown the Marcos heir ahead with a commanding 30-percentage point lead.
In the volatile Mindanao region, a grenade attack outside a polling station late on Sunday left nine people injured, said police, according to an AFP report.
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Whoever wins will take over from Rodrigo Duterte, the strongman leader who's come to the end of his six year term in office.
Mr Duterte's government has been criticised for its brutality in cracking down on drugs and crime, though the administration has always rejected allegations of wrongdoing.
Critics say democratic institutions have come under attack during Mr Duterte's presidency, pointing to the shutdown of Philippines' broadcaster ABS-CBN, a channel which has in the past angered Mr Duterte - among others.
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